The Effect of Carbimazole Therapy on Interleukin 2, Interleukin 2 Receptors and Free Radicals
作者:
WilsonR.,
McKillopJ. H.,
BuchananL. M.,
BradleyH.,
SmithW. E.,
ThomsonJ. A.,
期刊:
Autoimmunity
(Taylor Available online 1990)
卷期:
Volume 8,
issue 1
页码: 3-7
ISSN:0891-6934
年代: 1990
DOI:10.3109/08916939008998426
出版商: Taylor&Francis
关键词: Carbimazole;Interleukin 2;Interleukin 2 Receptors;Free Radicals
数据来源: Taylor
摘要:
Levels of Interleukin 2 (IL2), IL 2 receptors (IL2R) and free radical scavengers were measured in 25 Graves' disease patients prior to and following an 8 week course of Carbimazole therapy in an attempt to understand the mechanism by which the drug acts on the immune system.In untreated Graves' patients IL2R levels were elevated and IL2 levels reduced. Free radical scavengers were also reduced in these patients. Following treatment IL2R levels fell and IL2 levels rose. Levels of the free radical scavengers also rose. It is not clear whether it is the fall in IL2R levels or the rise in the level of free radical scavengers (implying a reduction in free radical activity) which is responsible for the rise in IL2.
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