Sodium Kinetics Across Dialysis Membranes
作者:
Francesco Locatelli,
Renato Ponti,
Luciano Pedrini,
Riccardo Costanzo,
Salvatore Di Filippo,
Paolo Marai,
Claudio Pozzi,
期刊:
Nephron
(Karger Available online 1984)
卷期:
Volume 38,
issue 3
页码: 174-177
ISSN:1660-8151
年代: 1984
DOI:10.1159/000183303
出版商: S. Karger AG
关键词: Sodium diffusion;Sodium convection;Dialysate sodium concentration;Sieving coefficient;Donnan effect
数据来源: Karger
摘要:
The kinetics of sodium across dialysis membranes were studied during diffusion and during convection utilizing cuprophan and cellulose hydrate membranes. During diffusion the changes in plasma water sodium concentration are correlated to the sodium concentration gradient between plasma water and dialysate but an increase also occurs when the gradient is annulled, due to the Donnan effect. During convection the plasma water sodium concentration increases during the passage through the dialyzer and the ultrafiltrate sodium concentration is significantly lower than the plasma water sodium concentration; this is due to the fact that the plasma proteins, as anions unable to cross the membrane, affect the kinetics of the sodium cations. Therefore, during diffusion the kinetics of sodium are mainly affected by the sodium concentration gradient and by the plasma protein concentration, while during convection the plasma protein concentration is the main factor affecting the kinetics of sodium.
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