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Dopamine-dependent behavioural stimulation by non-peptide delta opioids BW373U86 and SNC 80: 2. Place-preference and brain microdialysis studies in rats

 

作者: R Longoni,   C Cadoni,   A Mulas,   G Di Chiara,   L Spina,  

 

期刊: Behavioural Pharmacology  (OVID Available online 1998)
卷期: Volume 9, issue 1  

页码: 9-14

 

ISSN:0955-8810

 

年代: 1998

 

出版商: OVID

 

关键词: BW 373U86;dopamine;microdialysis;place-preference;rat;sNC80

 

数据来源: OVID

 

摘要:

The motivational properties of the non-peptide δ-opioid receptor agonists BW373U86 and SNC 80 were investigated using the place-conditioning paradigm. BW373U86 (0.5–1.0 mg/kg s.c.) and SNC 80 (1.25–5.0 mg/kg s.c.) elicited significant preference for the drug-paired compartment, in a dose-related fashion. Naltrindole (5.0 mg/kg s.c.) pretreatment, while failing to modify preference when given alone, completely prevented place-preference induced by BW373U86 (1.0 mg/kg s.c.) and SNC 80 (1.25 mg/kg s.c.). The dopamine D1receptor antagonist SCH23390, given at doses that do not affect place-preference (0.012 mg/kg s.c.), completely prevented the place-preference induced by BW373U86 and SNC 80. At the doses effective in eliciting place-preference, BW373U86 and SNC 80 failed to modify extracellular dopamine in the medial nucleus accumbens, while in the dorso-lateral caudate-putamen BW373U86 (1.0 and 2.5 mg/kg s.c.) reduced extracellular dopamine, and this effect was prevented by naltrindole (5.0 mg/kg s.c.). SNC 80, only at the dose of 5 mg/kg s.c., significantly reduced extracellular DA in the dorso-lateral caudate-putamen. The results indicate that stimulation of δ-opioid receptors has incentive properties that might be related to an indirect amplification of post-synaptic dopamine transmission.

 

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