The major component of the oviposition attractant pheromone of the mosquitoCulex pipiens fatiganswas shown to be (-)-(5R, 6S)-6-acetoxy-5-hexadecanolide (1).1For the chemical synthesis of this optically active pheromone,2carbohydrates such as D-mannitol2iand 2-deoxy-D-ribose21have been utilized as chiral templates. In this laboratory the natural pheromone has been synthesized from (S)- and (R)-O,O-isopropylideneglyceraldehyde independently, using diastereoselective dihydroxylation as the key step.2mWe now describe an enantiospecific synthesis of the pheromone from D-glucose.