Testing Drugs on Human Osteoarthritic Articular Cartilage
作者:
J. Chayen,
Lucille Bitensky,
S. Mehdizadeh,
Jane Dunham,
J. Older,
期刊:
Cell Biochemistry and Function
(WILEY Available online 1994)
卷期:
Volume 12,
issue 1
页码: 63-68
ISSN:0263-6484
年代: 1994
DOI:10.1002/cbf.290120109
出版商: John Wiley&Sons, Ltd.
关键词: Osteoarthritis;non‐steroidal anti‐inflammatory drugs;organ maintenance culture;quantitative cytochemistry
数据来源: WILEY
摘要:
AbstractNew drugs are generally developed against animal models of the human disease. Before they are subjected to clinical trials it might be helpful to be able to test whether they are as effective against the disease in human tissue as they were in animals. It is proposed that this can be achieved by the use of organ maintenance culture of the human diseased tissue, the relevant biochemical parameters being measured by quantitative cytochemistry. In the present studies differences between the effect of indomethacin and of the ‘chondroprotective’ drug diclofenac sodium, on human osteoarthritic cartilage, have been measu
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