SummaryThe authors administered a combination chemotherapy with nitrogen mustard, vincristine, procarbazine and prednisone to 37 cases of Hodgkin’s disease at advanced stages.Very encouraging results were obtained in previously untreated patients: 82.3% remissions with a plateau around 80 % remission and survival durations up to four years. Thus, the cure of such an advanced disease becomes conceivable, but the appearance of secondary cancers is possible.On the contrary, in previously treated patients, the results are less favourable: only 30% remissions are achieved with a median survival duration of responders around two years. Moreover, the haematologic toxicity is not negligible in this last group.