Neutrophil Function in Chronic Neutrophilic Leukemia: Defective Respiratory Burst in Response to Phorbol Esters
作者:
Sandra S. Kaplan,
Roger L. Berkow,
Robert A. Joyce,
R.E. Basford,
James C. Barton,
期刊:
Acta Haematologica
(Karger Available online 1992)
卷期:
Volume 87,
issue 1-2
页码: 16-21
ISSN:0001-5792
年代: 1992
DOI:10.1159/000204707
出版商: S. Karger AG
关键词: C kinase;Leukemia;Neutrophils;Phorbol esters
数据来源: Karger
摘要:
Functional analyses were performed on neutrophils isolated from 6 patients from two institutions who displayed features of chronic neutrophilic leukemia (CNL). These neutrophils demonstrated a consistent deficiency (44 ± 8% of control values) in superoxide anion (O-2) production in response to the phorbol ester, phorbol myristate acetate (PMA). O-2 production in response to chemotactic peptides was near normal (82.3 ± 10.7% of control values). Bacterial killing was normal in the two patients studied, and chemotaxis was diminished in response to zymosan-activated plasma and to high concentrations of chemotactic peptides in the patients studied. Cytosolic C kinase activity was decreased in one of the two patients studied. These results suggest that a deficient O-2 release in response to PMA is a hallmark of neutrophils in CNL and may provide a diagnostic indicator of this conditio
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