Cefamandole in the Treatment of Soft Tissue Infections
作者:
C.H. Ramírez-Ronda,
R. Quiñones-Soto,
A. Lugo-Velázquez,
R.H. Bermúdez,
期刊:
Chemotherapy
(Karger Available online 1982)
卷期:
Volume 28,
issue 3
页码: 224-228
ISSN:0009-3157
年代: 1982
DOI:10.1159/000238081
出版商: S. Karger AG
关键词: Cefamandole nafate;Gram-positive cocci;Gram-negative rods;Safety
数据来源: Karger
摘要:
27 male adult patients with acute soft tissue infections including cellulitis, abscesses, ulcers and wound infections were treated with a dose of 2–4 g/day of cefamandole nafate by the intravenous route for a minimum of 10 days. Most patients were seriously ill with underlying conditions like diabetes mellitus, alcoholism and congestive heart failure and required hospitalization and parenteral antibiotics. Gram-positive cocci (predominantly Staphylococcus aureus) and gram-negative bacilli were recovered on pretreatment cultures from 81% of the patients. Clinical and beacteriologic response was excellent. Disappearance of the signs of infection occurred by the 7th day of treatment, by day 3 of treatment fever was down to normal, and by day 5 of treatment the WBC count was below 8,000. There were very few side effects noted, and there was excellent tolerance to the intravenous drug administration. Cefamandole nafate is a safe, effective and well-tolerated agent in the treatment of skin and soft tissue infections of adult patients caused by susceptible organism
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