Mechanism of sperm‐binding inhibition by anti‐zona antisera
作者:
R. J. Aitken,
D. W. Richardson,
期刊:
Gamete Research
(WILEY Available online 1981)
卷期:
Volume 4,
issue 1
页码: 41-47
ISSN:0148-7280
年代: 1981
DOI:10.1002/mrd.1120040107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: zona pellucida;antibody;sperm receptors
数据来源: WILEY
摘要:
AbstractMouse zonae pellucidae contain receptors for sperm throughout their structure since spermatozoa will bind to both the inner and outer surfaces of isolated zona fragments. Antibodies raised against mechanically isolated mouse zonae pellucidae were only capable of suppressing sperm binding to the outer zona surface in association with the formation of a precipitate in this region.These results indicate that such antisera are not capable of interacting directly with the sperm receptors on the zona pellucida but rely upon the less efficient mechanism of steric hindrance to prevent sperm from gaining access to the sperm binding sites.
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