Effect of polychlorinated biphenyls (PCBs) on phospholipid membrane fluidity
作者:
Terry Reich,
M.C. Depew,
G.S. Narks,
M.A. Singer,
J.K.S. Wan,
期刊:
Journal of Environmental Science and Health . Part A: Environmental Science and Engineering
(Taylor Available online 1981)
卷期:
Volume 16,
issue 1
页码: 65-71
ISSN:0360-1226
年代: 1981
DOI:10.1080/10934528109374963
出版商: Taylor & Francis Group
关键词: PCBs;Biophysical interaction;Phospholipid Membrane;Membrane Fluidity;Spin Label Study
数据来源: Taylor
摘要:
Polychlorinated biphenyls (PCBs) are highly lipophilic molecules that are now widely distributed throughout the environment. They tend to accumulate in the adipose tissue and thus remain as a source of continuing exposure to the rest of the body. The interaction of some of the representative PCBs with phospholipid bilayer membranes was monitored by the spin label technique. Under identical experimental conditions, it was found that an increase in chlorine substitution in the 2,2’, 6,6'‐positions of the biphenyl rings enhances the motion of the spin label in the bilayer membrane. It is proposed that the perturbation which increases the membrane fluidity can be correlated to the degree of non‐coplanarity of the biphenyl rings incorporated into the bilayer membranes.
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