ACUTE GRAFT-VERSUS-HOST DISEASE WITHOUT COSTIMULATION VIA CD281
作者:
Speiser2,3 Daniel,
Bachmann2 Martin,
Shahinian4 Arda,
Mak2,4 Tak,
Ohashi2 Pamela,
期刊:
Transplantation
(OVID Available online 1997)
卷期:
Volume 63,
issue 7
页码: 1042-1044
ISSN:0041-1337
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
T lymphocyte activity is enhanced by costimulatory signals mediated through CD28 binding to B7-1/B7-2 on antigen-presenting cells. Several recent studies have shown that graft-versus-host disease (GVHD) can be inhibited by in vivo treatment with CTLA4Ig, which blocks CD28-B7 interactions. These findings prompted us to investigate the role of CD28 in acute GVHD, using gene-targeted mice. We performed the experiments in the context of strong allogeneic MHC stimulation (H2banti-H2d) and weak stimulation (H2danti-H2b). In both directions, efficient in vitro T-cell cytotoxicity and acute lethal GVHD were induced by CD28-deficient lymphocytes, which was only partially delayed when compared with wild-type mice. We conclude that lethal GVHD can develop without costimulation via CD28.
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