Oxidative Stress Changes in L‐Arginine‐Induced Pancreatitis in Rats
作者:
Ilona Varga,
Bela Matkovics,
Laszlo Czako,
Do Hai,
Marta Kotorman,
Tamas Takacs,
Maria Sasvari,
期刊:
Pancreas
(OVID Available online 1997)
卷期:
Volume 14,
issue 4
页码: 355-359
ISSN:0885-3177
年代: 1997
出版商: OVID
关键词: Lipid peroxidation;Antioxidant enzymes;L-Arginine;Acute pancreatitis
数据来源: OVID
摘要:
The important role of oxygen radicals in acute experimental pancreatitis was demonstrated by study of the changes in the antioxidant system in the blood, liver, kidney, and pancreas of rats after the administration of a large quantity of L-arginine (L-Arg). The changes in lipid peroxidation and in reduced and oxidized glutathione were followed, as well as the activities of peroxide-decomposing enzymes (glutathione peroxidase and catalase) and H2O2-producing superoxide dismutases. The results demonstrated that “oxidative stress” develops and acute pancreatitis appears rapidly after L-Arg treatment. Oxidative stress symptoms are expressed 24 h after the final treatment. Slow restitution of the studied antioxidant system can be demonstrated as early as after 48 h.
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