Utilisation du fructose par I'hépatocyte isolé de rat nourri Zucker obèse fa/fa.
作者:
Nathalie Serbource-Goguel,
Dominique Porquet,
Jeanne Feger,
Geneviêve Durand,
Marline Appel,
Jean Agneray,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1985)
卷期:
Volume 29,
issue 2
页码: 119-128
ISSN:0250-6807
年代: 1985
DOI:10.1159/000176969
出版商: S. Karger AG
关键词: Fructose;Isolated hepatocytes;Zucker obese rat;Fed rat
数据来源: Karger
摘要:
The utilization of fructose by isolated hepatocytes was investigated in fed obese Zucker fa/fa rats compared with their lean littermates (Fa/?) and Sprague-Dawley rats. Hepatocytes were incubated during 3 h using U14C fructose (20 mM). Our results show: a significant increase of fructose consumption, glucose, lactate and pyruvate production and faster turnover of glycogen by fa/fa rats. In these animals, synthesis of acylglycerol was also significantly enhanced. Our results suggest that fructose in fa/fa rats was used preferentially as precursor for lipid synthesis not only by the liver but also by the adipose tissue after a prior transformation into glucose by hepatocytes. All these abnormalities result in an accumulation of acylglycerols maintaining an obesity state in fa/fa rats.
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