Interstitial Nephritis Associated with 5-Aminosalicyclic Acid
作者:
Torsten Witte,
Christoph J. Olbricht,
Karl M. Koch,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 4
页码: 481-482
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188024
出版商: S. Karger AG
关键词: Interstitial nephritis;5-Aminosalicylic acid
数据来源: Karger
摘要:
A patient with severe Crohn’s disease was treated with 5-aminosalicylic acid (5-ASA). Following initiation of treatment, serum creatinine increased slowly from 105 to 530 μmol/l (creatinine clearance 16 ml/min). The diagnosis of an interstitial nephritis was made based on normal urinary findings and the renal biopsy histology of intestitial mononuclear infiltrates and normal glomeruli, 5-ASA was discontinued and serum creatinine decreased to 245 μmol/l (creatinine clearance 40 ml/min) during the following 3 months. Partial reversibility of renal failure following discontinuation of 5-ASA and the absence of other drugs possibly causing interstitial nephritis suggest a causal relationship between 5-ASA and interstitial nephri
点击下载:
PDF
(319KB)
返 回