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Exact Tests forin SituHybridization Experiments

 

作者: KeithA. Soper,   Philip Troilo,  

 

期刊: Journal of the American Statistical Association  (Taylor Available online 1992)
卷期: Volume 87, issue 417  

页码: 78-83

 

ISSN:0162-1459

 

年代: 1992

 

DOI:10.1080/01621459.1992.10475177

 

出版商: Taylor & Francis Group

 

关键词: Cytogenetics;Experiment-wide error rate;Nonparametric test

 

数据来源: Taylor

 

摘要:

Radioactively labeled gene probes are observed as “grains” that identify specific sites of hybridization within chromosomes, suggesting potential sites for a target gene. Based on the resolution of the assay, chromosomes are subdivided into bins of approximately equal length, and the number of grains in each bin is tallied. To distinguish true hybridization sites from nonspecific binding, we propose a test statistic,Zmax, based on the number of grains in any two adjacent bins. An efficient algorithm for the exact null distribution ofZmaxis provided, as well as power calculations and a large-sample approximation. A step-down method that protects the experiment-wide error rate is given to identify multiple hybridization sites.

 

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