&NA;Ongoing developments in prenatal diagnosis, coupled with methods of pregnancy intervention and termination, have brought the demands of fetal medicine to the doorstep of general pathology. The requirements for comprehensive fetal examinations are remarkably diverse, ranging from gross to microscopic to molecular evaluation. Pathologists, as essential members of a diagnostic team that includes ultrasonographers, obstetricians, perinatologists, medical geneticists, nurses, and others, must obtain data and tissue that facilitates diagnosis, either at the time of examination or at a later date, as indications for testing become apparent. To do this, pathologists must understand a wide variety of artifacts, changes unique to the fetus, and congenital disorders, and they should be familiar with the medical‐legal and ethical demands of practice. This review introduces practical techniques of dissection; acquisition and preservation of data; and tissue collection, storage, and testing. It also includes recommendations for the operation of a fetal pathology service. Approaches to the study of macerated, disrupted, or hydropic fetuses are given, and the work‐up of certain representative conditions (velocardiofacial syndrome, Fanconi anemia, glomerulocystic disease, and trisomy 21) is presented.