Akinetic MutismDisconnection of Frontal‐Subcortical Circuits
作者:
Michael Mega,
Robert Cohenour,
期刊:
Neuropsychiatry, Neuropsychology & Behavioral Neurology
(OVID Available online 1997)
卷期:
Volume 10,
issue 4
页码: 254-259
ISSN:0894-878X
年代: 1997
出版商: OVID
关键词: Neurobehavior;Akinetic mutism;Globus pallidus
数据来源: OVID
摘要:
SummaryAkinetic mutism may result from anterior cingulate lesions or a disconnection of the limbic connections projecting from the cingulate through sub-cortical circuits. Based on nonhuman primate tracer studies, ventral pallidal lesions should disrupt the anterior cingulate frontal-subcortical circuit. A patient developed a rigid akinetic mute state caused by bilateral lesions of the globus pallidus interna with ventral extension. The anatomic basis of the patient's clinical findings support a similarity in frontal-subcortical anatomy between humans and nonhuman primates. Isolated pallidal lesions are rare. Future studies should document whether ventral extension below the anterior commissure is associated with a loss of motivation.
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