Studies in animal models and humans suggesting a role of nerve growth factor in schizophrenia‐like disorders
作者:
L. Aloe,
A. Iannitelli,
F. Angelucci,
G. Bersani,
M. Fiore,
期刊:
Behavioural Pharmacology
(OVID Available online 2000)
卷期:
Volume 11,
issue 3 & 4
页码: 235-242
ISSN:0955-8810
年代: 2000
出版商: OVID
关键词: nerve growth factor;brain‐derived neurotrophic factor (BDNF);neurotrophins;behavior;maldevelopment;schizophrenia, animal models
数据来源: OVID
摘要:
Neurotrophic factors, such as nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF), are known to play a crucial role in growth, differentiation and function in a variety of brain neurons during development and in adult life. We have recently shown that environmental changes, aggressive behavior and anxiety‐like responses alter both circulating and brain basal NGF levels. In the present review, we present data obtained using animal models which suggest that neurotrophic factors, particularly NGF and BDNF, might be implicated in mechanism(s) leading to a condition associated with schizophrenic‐like behaviors. The hypothesis that neurotrophins of the NGF family can be implicated in some maldevelopmental aspects of schizophrenia is supported by findings indicating that the constitutive levels of NGF and BDNF are affected in schizophrenic patients.
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