Exaggerated Sympathetic Responses to Bradykinin in Spontaneously Hypertensive Rats
作者:
RUBEN BUNAG,
HAKUO TAKAHASHI,
期刊:
Hypertension
(OVID Available online 1981)
卷期:
Volume 3,
issue 4
页码: 433-440
ISSN:0194-911X
年代: 1981
出版商: OVID
关键词: Mood pressure;6-hydroxydopamine;spontaneous hypertension;supramedullary brain centers;sympathetic nerve activity
数据来源: OVID
摘要:
SUMMARY Possible defects in blood pressure (BP) regulation were studied by recording responses to centrally-administered bradykinin. Pressor effects accompanied by increased sympathetic nerve activity were elicited by intracerebroventricular injections in intact rate, but significant differences between Kyoto-Wistar normotensive (KNR) and spontaneously hypertensive rats (SHR) were not detected. By contrast, intracarotid injections into cross-perfused head preparations consistently produced more prominent systemic effects in SHR than in KNR, and these differences became even more pronounced following carotid denervation. After destruction of central noradrenergic neurons in KNR by intracerebroventricular injection of 6-hydroxydopamlne (6-OHDA), responses to bradykinin became the same as those in SHR. These results are in accord with the interpretation that a-adrenergic mechanisms for Mood pressure regulation in supramedullary brain areas no longer function normally in SHR and that a similar dysfunction can be induced in KNR by pretreatment with 6-OHDA.
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