Inherited, selective hypoanalgesic response to cytisine in the tail‐flick test in CF‐1 mice
作者:
Thomas Seale,
Raha Nael,
Satendra Singh,
Garo Basmadjian,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 2
页码: 201-205
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Analgesia/pain;Cytisine;Lethality;Locomotor activity;Nicotine;Nicotinic cholinergic agonists;Pharmacogenetics;Seizures;Tail-flick test
数据来源: OVID
摘要:
THIS study extends the pharmacological characterization of the genotype-dependent difference in analgesic responsiveness to neuronal nicotinic agonists between CD-1 and CF-1 strains of mice. Acute analgesic potency of cytisine measured by the tail-flick assay differed by > 3200-fold between CD-1 and CF-1 outbred strains of mice. Analgesic non-responsiveness of the CF-1 strain was pharmacologically selective. Morphine produced a dose-dependent analgesic response of similar magnitude in both strains. Other pharmacological actions of cytisine, including inhibition of locomotor activity, induction of seizures and lethality, did not differ between these strains. Hyporesponsiveness to the analgesic action of both nicotine and cytisine was observed in two different CF-1 sublines. Biodistribution of [3H]cytisine in blood did not differ between the CF-1 and CD-1 strains. These pharmacological characteristics indicate that the CD-1–CF-1 strain pair provides a useful pharmacogenetic tool for investigating the mechanistic bases of analgesia induced by nicotinic cholinergic agonists.
点击下载:
PDF
(295KB)
返 回