ObjectiveTo determine the association between ambulatory blood pressure (ABP) and central hemodynamics in hypertensive patients and between the area under the 24-h blood pressure curve and the hemodynamic indexes.Patient population:Forty untreated essential hypertensive patients (28 previously untreated, 12 withdrawn from therapy for > 12 weeks).Methods:Patients underwent casual and 24-h ABP monitoring and invasive measurements of central hemodynamics. Central measures of ABP included 24-h mean, awake, and sleep values guided by activity journals. The ABP data were modeled by Fourier series and the ability of the smoothed and unsmoothed data to predict hemodynamics was compared. Individual blood pressure curves were analyzed by calculating the area under the curve using different threshold awake and sleep values to test the correlations between this form of blood pressure load and hemodynamics.Results:Hemodynamic measures were not predicted by casual blood pressure but were related to ABP. Total peripheral resistance was strongly predicted by the area under the diastolic blood pressure (DBP) curve using an awake threshold of 90 mmHg and a sleep threshold of 80 mmHg (r = 0.56,P<0.001). Data smoothing using Fourier transformation did not alter any correlations between ABP and hemodynamics. Exercise stroke index, an indicator of cardiac function impaired in early hypertensive heart disease, was also best predicted by area under the DBP curve using the same thresholds as above (r=-0.56,P<0.001).Conclusions:These data imply that integrated areas under the ABP curve are related to hemodynamic hypertensive indexes and could be used to assess the extent of hypertensive burden in clinical trials.