Glycosaminoglycans and Oxalocalcic Urolithiasis
作者:
F. Grases,
I. Llompart,
A. Conte,
R. Coll,
J.G. March,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 68,
issue 4
页码: 449-453
ISSN:1660-8151
年代: 1994
DOI:10.1159/000188306
出版商: S. Karger AG
关键词: Dimethylmethylene blue;Glycosaminoglycans;Oxalocalcic urolithiasis
数据来源: Karger
摘要:
A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males and females) and in the control group; moreover, in some individual cases, a deficit of urinary GAGs was clearly detected. Apart from important inhibitory effects of GAGs on heterogenous calcium oxalate nucleation, the low urinary GAG content could be the cause of a pathological epithelium, favoring stone formation. The dimethylmethylene blue method is recommended as a quick screening procedure to determine a GAG deficit.
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