The Pupillary Light Reflex. 2. Prevalence of Pupillary Autonomic Neuropathy in Diabetics Using Age-Dependent and Age-Independent Pupillary Parameters
作者:
Rainer Hans Straub,
Andreas Jeron,
Lothar Kerp,
期刊:
Ophthalmologica
(Karger Available online 1992)
卷期:
Volume 204,
issue 3
页码: 143-148
ISSN:0030-3755
年代: 1992
DOI:10.1159/000310283
出版商: S. Karger AG
关键词: Diabetes;Pupillary light reflex;Diabetic autonomic neuropathy;Prevalence of late complications
数据来源: Karger
摘要:
Seventy-seven diabetics with a duration of the disease ranging from 2 to 55 years (average 18.5 years) were studied with infrared videopupillometry. The prevalence of diabetic autonomic neuropathy at the pupillary control system (pANP) was studied comparatively using several pupillary tests. The average prevalence using age-dependent parameters was 30.2% [maximal pupillary area: 22.1%, maximal contraction velocity: 24.7%, contraction velocity at Is (CV1): 28.6%, and dilation velocity at 6 s (DV6): 45.5% ]. Comparing these percentages to prevalences of other diabetic late complications e. g. retinopathy (49.4%), DV6 seems to be good for the diagnosis of pANP. If CV1 and DV6 are expressed in percent of the maximal pupillary area (CV1% and DV6%), they become age-independent. The average CV1% andDV6% of diabetics differ highly significantly from those of normals (CV1%: 58.6 ± 14.5 vs. 64.1 ± 6.4%, 2 p < 0.005, and DV6%: 6.0 ± 2.9 vs. 7.3 ± 1.1%, 2 p < 0.001). The average prevalence of pANP using these age-independent parameters was 25.4%. These data suggest that the prevalence of p ANP especially disorders of pupillary dilation (DV6), is high in long-standing diabetes. Furthermore, CV1% and DV6% have proved to be valid parameters in finding differences in the light reflex in non-age-matched study gro
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