Hodgkin's disease frequently involves the spleen. Careful histologic sections of the spleen are required to rule out involvement since the involved spleen may occasionally be of normal size. Vascular invasion may be the mode of splenic involvement. The spleen plays an important role in the body's immune function. Since splenectomized children with Hodgkin's disease are prone to fulminant infections, these patients should be kept under careful surveillance. The value of penicillin prophylaxis and the pneumococcal vaccine in these patients is still under consideration.