SummaryThe effect of oral administration of G 33182 has been studied in cedema-tous cardiac patients. The diuresis and saluresis caused by G 33182 are quick, considerable and sustained during about 72 hours. Potassium loss was moderate and did not produce hypokaliemia or clinical symptoms. A 400 mg dosis taken two to four times, at 48 to 72 hours intervals, allows complete elimination of voluminous oedema; the maintenance dosage should not exceed 400 mg once or twice a week. Work done by others points to a lower dosis (200 or even 100 mg) as having a maximal diuretic effect. No signs of toxicity were noted at the dosages used.