ANALYSIS OF SECRETION AND EXPRESSION OF PLATELET‐DERIVED GROWTH FACTOR IN CULTURED ENDOTHELIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RAT
作者:
Koji Iihara,
Masakiyo Sasahara,
Yukikazu Saeki,
Nobuo Hashimoto,
Haruhiko Kikuchi,
Fumitada Hazama,
期刊:
Clinical and Experimental Pharmacology and Physiology
(WILEY Available online 1993)
卷期:
Volume 20,
issue 7‐8
页码: 515-521
ISSN:0305-1870
年代: 1993
DOI:10.1111/j.1440-1681.1993.tb01734.x
出版商: Blackwell Publishing Ltd
关键词: atherosclerosis;endothelium;hypertension;platelet‐derived growth factor.
数据来源: WILEY
摘要:
SUMMARY1. We characterized the endothelial cell‐derived growth factors of SHRSP and Wistar Kyoto rats (WKY), respectively and found that platelet‐derived growth factor (PDGF)‐B chain related growth factor constituted a major portion of the mitogenic activity of the conditioned media of endothelial cells from both animals. There were no remarkable qualitative differences between the endothelial cell‐derived growth factors of SHRSP and WKY.2. Northern analysis revealed that the expression of PDGF‐B chain was 2–4‐fold enhanced in cultured aortic endothelial cells of SHRSP. This enhanced expression of PDGF‐B chain, which may be induced under chronic hypertensive conditions, is suggested to contribute to the increase in endothelial cell‐derived growth factors report
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