Influence of Age on the Pharmacokinetics of AlfentanilGender Dependence
作者:
Harry J.M. Lemmens,
Anton G.L. Burm,
Pim J. Hennis,
Marina P.P.R. Gladines,
James G. Bovill,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1990)
卷期:
Volume 19,
issue 5
页码: 416-422
ISSN:0312-5963
年代: 1990
出版商: ADIS
数据来源: ADIS
摘要:
Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = −0.79, p < 0.001) between plasma alfentanil clearance (CL) and age in women (<50y, median CL 24.84 L/h; > 50y, median CL 14.52 L/h), but not in men (<50y, median CL 19.44 L/h; >50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent.
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