AbstractAlthough gel permeation chromatography (GPC) was developed primarily for measuring the molecular size distribution of polymers, it has been extremely useful for analyzing materials of intermediate and low molecular weight. It is also in this range that properties of compounds other than molecular size appear to have the greatest effect on the elution characteristics of solutes. Therefore, in order to increase the effectiveness of GPC as an analytical tool, the elution behavior of about 100 model compounds was studied and this information used to assist in the interpretation of chromatograms.