Audiogenic priming in DBA/2J and C57BL/6J mice: Interactions among age, prime‐to‐test interval, and index of seizure
作者:
Robert A. Schreiber,
John M. Graham,
期刊:
Developmental Psychobiology
(WILEY Available online 1976)
卷期:
Volume 9,
issue 1
页码: 57-66
ISSN:0012-1630
年代: 1976
DOI:10.1002/dev.420090109
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractC57BL/6J mice, not susceptible to audiogenic seizures (AGS) on the 1st exposure to an acoustic stimulus, were exposed to the acoustic stimulus for 1 min and then tested at some later date (acoustic priming). They were first exposed at either 8, 16, 19, 22, or 28 days of age, and then tested for AGS 2‐16 days after priming. DBA/2J mice, susceptible to AGS on the 1st exposure to intense noise, were exposed to the acoustic stimulus at 26 days of age, and then again 2‐14 days later. Data indicate that the incidence of AGS upon the 2nd exposure to the acoustic stimulus is a function of age at priming, the prime‐to‐test interval in days, and the index of seizures. In the case of DBA mice, later effects are also dependent on the initial level of
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