One is the occurrence of hemorrhage as the end result of excessive clotting; another, the effectiveness of an anticoagulant in helping to curb the bleeding. A wide variety of disease states may produce the hypercoagulability that triggers the chain reaction leading to D I C. These include conditions that release procoagulants into the blood, slow blood flow, injure the vascular endothelium, or compromise the integrity of the liver and RES.