Heterosexual Transmission of Human Immunodeficiency Virus Type 1 from Transfusion Recipients to Their Sex Partners
作者:
Thomas O'Brien,
Michael Busch,
Elizabeth Donegan,
John Ward,
Leeyang Wong,
Susan Samson,
Herbert Perkins,
Ronald Altman,
Rand Stoneburner,
Scott Holmberg,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 7
页码: 705-710
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: HIV-1;Heterosexual transmission;Transfusion recipients;Incubation period;Epidemiology.
数据来源: OVID
摘要:
Summary:Using lookback procedures and other methods, we identified and then prospectively followed human immunodeficiency virus type 1 (HIV-1)-infected transfusion recipients and their sex partners to determine AIDS incidence and risks of heterosexual transmission of HIV-1. At enrollment, 7 of 32 (21.9%) female partners of male recipients were themselves infected with HIV-1, as compared with none of 14 male partners of female recipients (p = 0.08). No additional episodes of transmission were observed. The prevalence of advanced immunodeficiency at enrollment was similar in male and female recipients. Male recipients with advanced immunodeficiency (CD4+ lymphocyte count ≤0.20 × 109/L or a history of clinical AIDS) at enrollment were more likely to have infected their female partners (odds ratio = 7.9; p = 0.03) than men with neither condition. Similarly, AIDS-free survival, as estimated by the product-limit method, was lower among male transmitters than among male nontransmitters (p = 0.01). Transmission was not associated with frequency of unprotected vaginal intercourse. Our data suggest that HIV-1-infected men who develop immunodeficiency rapidly are more likely to infect their sex partners and that the greater efficiency of male-to-female HIV-1 transmission is not explained by a greater number of sexual contacts or more advanced immunodeficiency in index subjects.
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