Reciprocalin vitrointeractions between human herpesvirus‐6 and HIV‐1 Tat
作者:
Dario Luca,
Paola Secchiero,
Pasqualina Bovenzi,
Antonella Rotola,
Antonella Caputo,
Paolo Monini,
Enzo Cassai,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 9
页码: 1095-1098
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Human herpesvirus-6;HIV-1;tat;long terminal repeat transactivation
数据来源: OVID
摘要:
The transactivation induced by human herpesvirus 6 (HHV-6) on the HIV-1 promoter was studied both in the presence and in the absence of the retroviral transactivator protein (Tat) constitutively expressed in Jurkat cells. Jurkat-tatcells were infected with HHV-6, transfected with a plasmid containing HIV-1 long terminal repeat (LTR)/chloramphenicol acetyltransferase (CAT), and CAT assays were performed. HHV-6 infection in the presence of Tat resulted in significantly higher LTR activation than that observed by Tat or HHV-6 alone, indicating that HHV-6 and Tat interact synergically. Furthermore, it was demonstrated that expression of HIV-1tatinhibits HHV-6 replication, as shown by a 3.6–15.4-fold reduction in infectious yield. We suggest that HHV-6 could trigger HIV reactivation in HIV-seropositive patients which, in turn, could inhibit HHV-6 production.
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