Effect of the calcium channel blocker nitrendipine in normotensive and spontaneously hypertensive, diabetic rats on kidney morphology and urinary albumin excretion
作者:
Birgitte Nielsen,
Henning Grønbæk,
Ruth Østerby,
Allan Flyvbjerg,
期刊:
Journal of Hypertension
(OVID Available online 1999)
卷期:
Volume 17,
issue 7
页码: 973-981
ISSN:0263-6352
年代: 1999
出版商: OVID
关键词: diabetes;hypertension;kidney morphology;nitrendipine;rat;urinary albumin excretion
数据来源: OVID
摘要:
ObjectiveTo investigate the effect of nitrendipine on the development of renal changes in experimental diabetes.DesignStreptozotocin (STZ)-induced diabetic normotensive Wistar rats (WIS) and spontaneously hypertensive rats (SHR) were randomly allocated to nitrendipine treatment (250 mg/kg fodder) or placebo treatment for 6 months.MethodsBlood pressure was assessed by the tail-cuff method, urinary albumin excretion (UAE) was determined, and glomerular basement membrane (GBM) thickness, mesangial volume, and mean glomerular volume (MGV) were estimated by morphometric measurements.ResultsIn diabetic WIS, nitrendipine significantly reduced UAE after 2 months of treatment (P< 0.05), while no effect was was seen after 4–6 months. In diabetic SHR, no effect on UAE was seen at any time. Nitrendipine was unable to inhibit the renal and glomerular enlargement in diabetic WIS and SHR. Diabetes plus hypertension was associated with significant increase in GBM thickness, while diabetes or hypertension alone showed no significant increase in GBM. Nitrendipine treatment was unable to prevent increased GBM in diabetic SHR.ConclusionNitrendipine inhibits an early increase in UAE in normotensive, diabetic rats, but fails to sustain this effect in long-term diabetes. No effect of nitrendipine was observed in SHR.
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