Use of chemical, biochemical, and genetic markers in cancer epidemiology and risk assessment
作者:
Kari Hemminki,
期刊:
American Journal of Industrial Medicine
(WILEY Available online 1992)
卷期:
Volume 21,
issue 1
页码: 65-76
ISSN:0271-3586
年代: 1992
DOI:10.1002/ajim.4700210109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: DNA adducts;protein adducts;mutations;oncogenes;antioncogenes;oncoproteins;biological markers;exposure assessment
数据来源: WILEY
摘要:
AbstractNew molecular methods have been developed to be used in assessing exposure to and effects of genotoxic and carcinogenic compounds. DNA and protein adducts are measures or surrogates of target dose. Molecular methods are available to probe mutations in oncogenes, antioncogenes, and other specific genes. Furthermore, concentrations of oncoproteins can be determined in biological fluids. If a close link is established between these markers and risk of cancer, they can be used as independent endpoints in the prevention of cancer.
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