Spectrophotometric Method of Determination for Cycloserine Using Chlornil
作者:
A.M. Wahbi,
M.E. Mohamed,
M. Abounassif,
E. Gad-kariem,
期刊:
Analytical Letters
(Taylor Available online 1985)
卷期:
Volume 18,
issue 3
页码: 261-267
ISSN:0003-2719
年代: 1985
DOI:10.1080/00032718508066129
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Cycloserine has been determined by a spectrophotometric method based on n → charge-transfer complex formation with chloranil. The method involves addition of cycloserine solution to chloranil reagent in borate buffer of pH 9; and heating at 65°C for 45 min. The complex formed exhibits absorption maximum of 348 nm; and Amaxis linearly related to concentration over the range 2–8 μg/ml. The mean percentage found for the authentic sample is 100.32 ± 0.70. When applied to commercial capsules claimed to contain 250 mg each, the mean percentage found is 102.45 ± 1.05. These results have shown good agreement when compared with those obtained by the pharmacopoeial (B.P.) methods.
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