Enkephalin‐immunoreactive nociceptive neurons in the cat spinal cord
作者:
A. Ribeiro-da-Silva,
Y. De Koninck,
A. Cuello,
J. Henry,
期刊:
NeuroReport
(OVID Available online 1992)
卷期:
Volume 3,
issue 1
页码: 25-28
ISSN:0959-4965
年代: 1992
出版商: OVID
关键词: Horseradish peroxidase;Electron microscopy, triple labelling;Autoradiography;Substance P;Enkephalin;Spinal cord;Dorsal horn
数据来源: OVID
摘要:
In this combined electrophysiological-ultrastructural study in the cat spinal cord, we detected enkephalin-like immunoreactivity using internally radio-labelled monoclonal antibodies in functionally characterized neurons which had been filled intracellularly with horesradish peroxidase. Of the 4 neurons included in this study, two were positive for enkephalin immunoreactivity; one was a nociceptive specific neuron in lamina I, the other a wide dynamic range neuron in lamina V. The other two cells were devoid of immunoreactivity for enkephalin; one was a wide dynamic range neuron and the other was a nonnociceptive neuron. These results thus provide a morphological substrate within the spinal dorsal horn for the release of an endogenous opioid following administration of substance P or noxious cutaneous stimulation.
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