Effects of Oxytocin Treatment Early in Pregnancy on Fetal Growth inad Libitum-Fed and Food-Restricted Rats
作者:
ANNICA SOHLSTRÖM,
CHRISTINE CARLSSON-SKWIRUT,
PETER BANG,
KERSTIN BRISMAR,
KERSTIN UVNÄS-MOBERG,
期刊:
Pediatric Research
(OVID Available online 1999)
卷期:
Volume 46,
issue 3
页码: 339-344
ISSN:0031-3998
年代: 1999
出版商: OVID
数据来源: OVID
摘要:
The effects of oxytocin on fetal and placental growth and on maternal weight gain and accumulation of body fat were studied inad libitum-fed and food-restricted (receiving 70% of the food intake of thead libitum-fed group) pregnant rats. Further, a possible role of the IGF axis in mediating oxytocin-induced changes was assessed. Pregnant rats were injected subcutaneously once a day during gestational d 1-5 with saline or oxytocin (1 mg/kg).Ad libitum-fed oxytocin-treated pregnant rats had higher circulating levels of IGF-I, larger placentas, fetuses, and newborn pups and contained less body fat at the end of pregnancy. In food-restricted dams, oxytocin-treatment had no effect on fetal and placental growth. Additionally, food restriction attenuated the normal increase in IGF binding protein-3 protease proteolysis during pregnancy. The results show that oxytocin may affect maternal adaptations to pregnancy and stimulate fetal growth. We suggest that this effect may be mediated by increased IGF-I inad libitum-fed animals, whereas food restriction may block this effect by resulting in low levels of circulating IGF-I and by attenuating the pregnancy-associated increase in IGF binding protein-3 protease activity and, thereby, further compromise IGF bioavailability.
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