Reduction of plasma levels of prothrombin fragments 1 and 2 during thromboprophylaxis with a low‐molecular‐weight heparin
作者:
J. Sørensen,
M. Lassen,
L. Borris,
H. Rahr,
H. Jensen,
D. Hoppensteadt,
J. Walenga,
J. Fareed,
期刊:
Blood Coagulation and Fibrinolysis
(OVID Available online 1992)
卷期:
Volume 3,
issue 1
页码: 55-60
ISSN:0957-5235
年代: 1992
出版商: OVID
关键词: F1+2;TDP;elective hip surgery;LMW-heparin;postoperative DVT
数据来源: OVID
摘要:
In a randomized double-blind placebo-controlled study, plasma levels of prothrombin fragment 1 and 2 and total fibrin/fibrinogen degradation products were measured preoperatively and on days 1, 3, 5 and 7 postoperatively in 131 patients undergoing total hip replacement. Patients received a subcutaneous injection of either a low molecular weight heparin (Logiparin™) or placebo once daily. Postoperative deep vein thrombosis was diagnosed by bilateral phlebography 7 to 10 days after operation. In the placebo group postoperative levels of prothrombin fragments 1 and 2 and total fibrin/fibrinogen degradation products were significantly higher in patients with postoperative thromboembolic complications, whereas in the low-molecular-weight heparin group no statistical differences were observed. Compared with placebo the administration of a low-molecular-weight heparin was associated with a significant reduction in the levels of prothrombin fragments 1 and 2 and total degradation products. Our observations suggest that the postoperative thrombin generation is moderated by thromboprophylaxis with Logiparin(tm).
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