Exposure analysis of dichotomous response measures in long-term studies
作者:
Karl E. Peace,
W. Hans Carter,
期刊:
Journal of Biopharmaceutical Statistics
(Taylor Available online 1993)
卷期:
Volume 3,
issue 1
页码: 129-140
ISSN:1054-3406
年代: 1993
DOI:10.1080/10543409308835053
出版商: Marcel Dekker, Inc.
关键词: Exposure analysis;Long-term CHD studies;Intent-to-treat
数据来源: Taylor
摘要:
Differential exposure to study medications in long-term studies of some cardiovascular compounds complicates analyses, particularly the usual intention-to-treat analyses and inferences therefrom of the data collected. Analysis methods that incorporate exposure are developed, presented, and illustrated by applying them to primary response data from a long-term, placebo-controlled, ancillary trial of gemfibrozil. The analysis methods address the extent to which end-points are correlated with the actual use of the compound rather than the extent to which end-points are correlated with the random assignment to double-blind study medications.
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