Effects of water-soluble marihuana-derived material (MDM) on the rabbit ciliary body: Light and electron microscopy
作者:
McDonaldThomas F.,
GreenKeith,
期刊:
Current Eye Research
(Taylor Available online 1986)
卷期:
Volume 5,
issue 6
页码: 457-464
ISSN:0271-3683
年代: 1986
DOI:10.3109/02713688609015115
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The response of the ciliary processes of the rabbit eye to water-soluble marihuana-derived material (MDM) has been examined with light and electron microscopy. Following intravenous injection of MDM, the processes undergo considerable swelling within 1 hour followed by thrombus formation in the capillaries and extravasation of red cells. Later phases include the formation of cysts between the non-pigmented and pigmented cell layers of the ciliary epithelium. The ciliary process edema coincides with the initial hypertensive phase seen after intravenous MDM, while the hematogenous response coincides with the fall in intraocular pressure. Following intravitreal injection of MDM, a similar pattern of structural changes occurs that accompanies a fall in intraocular pressure that lasts for several days; because the physiological response occurs over a longer time course (14–20 hours) relative to intravenous administration where the intraocular pressure changes occur rapidly, the ciliary process swelling phase does not result in an increase in intraocular pressure. The physiologic changes in the eye caused by MDM appear to be related to the induction of a general inflammatory response in the ciliary processes, with a primary effect on the vascular system.
点击下载:
PDF (853KB)
返 回