Disease associations and pathogenic role of antineutrophil cytoplasmic autoantibodies in vasculitis
作者:
J. Jennette,
Ronald Falk,
期刊:
Current Opinion in Rheumatology
(OVID Available online 1992)
卷期:
Volume 4,
issue 1
页码: 9-15
ISSN:1040-8711
年代: 1992
出版商: OVID
数据来源: OVID
摘要:
Antineutrophil cytoplasmic autoantibodies are a useful diagnostic serologic marker for a variety of well-known vasculitic syndromes, including Wegener's granulomatosis, polyarteritis nodosa (especially microscopic polyarteritis nodosa), Churg-Strauss syndrome, and pulmonary-renal syndrome with alveolar capillaritis. Although most patients with antineutrophil cytoplasmic autoantibody-associated disease have systemic disease, disease limited to one organ does occur,eg, isolated necrotizing glomerulonephritis, isolated respiratory tract disease, or isolated orbital disease. Antineutrophil cytoplasmic autoantibody titers may be useful in modulating treatment regimens. There isin vitroevidence that antineutrophil cytoplasmic autoantibodies are directly involved in the pathogenesis of antineutrophil cytoplasmic autoantibody-associated vasculitides.
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