Combined Conn’S And Cushing’S Syndrome: An Unusual Presentation Of Adrenal Adenoma.
作者:
BaertD.,
NobelsF.,
Van CrombruggeP.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1995)
卷期:
Volume 50,
issue 5
页码: 310-313
ISSN:1784-3286
年代: 1995
DOI:10.1080/17843286.1995.11718468
出版商: Taylor&Francis
数据来源: Taylor
摘要:
SummaryIn most aldosterone-producing adenomas (APA) dedifferentiation occurs with formation of transitional cells, bearing characteristics of both glomerulosa and fasciculata cells. These cells are able to produce Cortisol, and their aldosterone production follows the circadian rhythm of ACTH. Usually, no clinical signs of Cortisol excess develop, since the Cortisol production remains under ACTH feedback control. Only a few cases have been described with autonomous Cortisol secretion, not suppressible by low dose dexame-thasone. We present a patient with an APA, synthesizing enough Cortisol to cause the typical clinical expression of Cushing’s syndrome. Possible etiopathological mechanisms are discussed.
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