SummaryThe authors describe 2 severe cases of acute cyanide poisoning, treated and cured by injection of sodium thiosulfate.They describe the symptomatology and physiopathology of this poisoning. Therapy consists in injections of sodium thiosulfate, nitrites and methylene blue. The action of these antidotes is explained.Glycosuria which was present in both cases, and which is a clinical symptom of cyanide poisoning, has certainly a renal cause, since there is no hyperglycemia.Although, at this moment, the«seuil d’apparition»of glucosuria (minimal threshold) is lowered, a study of the renal function showed in both cases a normal glomerular filtration and a tubular maximal capacity reabsorption for glucose (TmG) similar to the values observed in normal subjects with the same glomerular filtration. The coexistence of a lowered minimal threshold with a normal tubular maximal capacity for glucose reabsorption may be a characteristic of cyanide poisoning after treatment has been applied or when the toxic condition is receding.