Beta‐adrenergic dilator interaction with the constrictor response in resistance vessels of skeletal muscle during hemorrhage
作者:
JAHN HILLMAN,
JAN LUNDVALL,
期刊:
Acta Physiologica Scandinavica
(WILEY Available online 1980)
卷期:
Volume 108,
issue 1
页码: 77-83
ISSN:0001-6772
年代: 1980
DOI:10.1111/j.1748-1716.1980.tb06502.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
A marked β‐adrenergic dilator interaction with the vasoconstrictor response in skeletal muscle during hemorrhage is described. The dilator influence corresponded to some 40% of the constrictor response both at mild and moderate as well as at large bleeding. In absolute resistance units, the β‐adrenergic dilator influence averaged no less than 14 mmHg/(mlXmin‐1X 100 g‐1) at large bleeding (hemorrhagic hypotension of 50 mmHg). Comparison of the hemorrhage induced resistance effects in the autoperfused innervated muscle, in the autoperfused denervated muscle, and in the innervated muscle cross‐circulated from a donor animal, showed that the β‐adrenergic dilator influence more or less completely was caused by blood‐borne catecholamines, in all likelihood by adrenaline, which is known to be secreted in large amounts during hemorrhage. The described β‐adrenergic dilator mechanism may serve to maintain nutritional blood flow by counteracting the constrictor response. It deserves consideration also from the point of view that it obviously has to be taken into account for proper evaluation of other vascular control mechanisms brought into a
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