The Neuropeptide Alpha-Melanocyte-Stimulating Hormone: A Key Component Neuroimmunomodulation
作者:
Anna Catania,
James M. Lipton,
期刊:
Neuroimmunomodulation
(Karger Available online 1994)
卷期:
Volume 1,
issue 1
页码: 93-99
ISSN:1021-7401
年代: 1994
DOI:10.1159/000097096
出版商: S. Karger AG
关键词: Inflammation;Fever;Adult respiratory distress syndrome;Septic shock;Endotoxemia;Rheumatoid arthritis;Myocardial infarction;Acquired immunodeficiency syndrome
数据来源: Karger
摘要:
Recent research indicates that the proopiomelanocortin derivative α-melano-cyte stimulating hormone (α-MSH) is a significant modulator of host reactions including fever and inflammation. Although the precise mechanism of action is still unknown, cytokine antagonism is believed to be responsible for at least a part of its anti-inflammatory/antipyretic influence:α-MSH antagonizes pyrogenic and proinflammatory effects of cytokines such as interleukin-1(IL-1), interleukin-6 (IL-6), tumor necrosis factor (TNF), and interferonγ(IFNγ).Although it is clear that the peptide can act within the brain to inhibit fever and peripheral inflammation, an anti-inflammatory effect on a peripheral target was evidenced in animals with transection of the spinal cord. Recent data show thatα-MSH is significant also in human disorders such as AIDS, rheumatoid arthritis, and myocardial infarction. This molecule is believed to be a key factor in neuroirnmunomodulation and it may be useful as a therapeutic agent in control of inflammatory reactions.
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