Linkage of Essential Hypertension to Chromosome 18q
作者:
Kristleifur Kristjansson,
Andrei Manolescu,
Arni Kristinsson,
Thordur Hardarson,
Helga Knudsen,
Sigurdur Ingason,
Gudmar Thorleifsson,
Michael Frigge,
Augustine Kong,
Jeffrey Gulcher,
Kari Stefansson,
期刊:
Hypertension: Journal of The American Heart Association
(OVID Available online 2002)
卷期:
Volume 39,
issue 6
页码: 1044-1049
ISSN:0194-911X
年代: 2002
出版商: OVID
关键词: genetics;population;hypertension, essential
数据来源: OVID
摘要:
We performed a genomewide scan with 904 microsatellite markers using 120 extended Icelandic families with 490 hypertensive patients. The families were identified by cross-matching a list of hypertensive patients from the Hypertension Clinic of the University Hospital (Landspitalinn) in Iceland with a genealogy database of the entire Icelandic nation. After adding 5 markers, we found linkage to chromosome 18q with an allele-sharing LOD score of 4.60 (P=2.1× 10−6). These results provide evidence for a novel susceptibility gene for essential hypertension on chromosome 18q and show that it is possible to study the genetics of essential hypertension without stratifying by subphenotypes.
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