Functional network differences in schizophreniaa rCBF study of semantic processing
作者:
Janine Jennings,
Anthony McIntosh,
Shitij Kapur,
Robert Zipursky,
Sylvain Houle,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 8
页码: 1697-1700
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Frontal lobes;Fronto-temporal dysconnectivity;Functional networks;Regional cerebral blood flow;Schizophrenia
数据来源: OVID
摘要:
STUDIES of regional cerebral blood flow in patients with schizophrenia have led to the idea that dysfunctional neurocircuitry may play a role in patients' cognitive deficits. The present PET study was designed to explore this idea by comparing the functional neural networks associated with semantic processing for patients and normal controls through structural equation modeling (path analysis). The patients showed significantly different neural interactions among frontal regions, between the frontal and temporal cortices, and between the frontal lobe and anterior cingulate than controls. These discrepancies were especially striking given there were minimal group differences in task performance. Results suggest that schizophrenia involves a neural abnormality that is evident in functional networks during cognitive performance.
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