Absence of Inhibitory Dopaminergic Control of the Rabbit Pituitary Gland Intermediate Lobe
作者:
Sarah Schimchowitsch,
J. Maria Palacios,
Marie Elisabeth Stoeckel,
Gabrielle Schmitt,
Aimé Porte,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 1
页码: 71-74
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124251
出版商: S. Karger AG
关键词: Intermediate lobe;Rabbit;Mouse;Dopamine receptors;α-MSH release
数据来源: Karger
摘要:
No immunoreactive axons were detected with an antiserum against tyrosine hydroxylase in the rabbit intermediate lobe (IL), which thus appears to be devoid of dopaminergic (DA) innervation. Dopamine and its agonists, which classically inhibit α-MSH release have no inhibitory effects on rabbit IL superfused in vitro but, paradoxically, stimulate α-MSH release. D2 type DA receptors, known to mediate inhibitory control of dopamine on melanotropic cells, and detectable by their affinity for (3H)-spiroperidol, were as previously reported absent from the rabbit IL. The absence of (3H)-spiroperidol binding sites in the IL was further confirmed on rabbit pituitary sections by radioautography. The mechanism of DA stimulation is still not clear, but might be tentatively explained by interference with other receptors involved in the stimulation of the gland. The lack of DA inhibitory control over the rabbit IL is an exception among the species so far studie
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