Evidence from Zaire that breast‐feeding by HIV‐1-seropositive mothers is not a major route for perinatal HIV‐1 transmission but does decrease morbidity
作者:
Robert Ryder,
Tarande Manzila,
Ekungola Baende,
Uwa Kabagabo,
Frieda Behets,
Veronique Batter,
Edward Paquot,
Enbonga Binyingo,
William Heywardt,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 6
页码: 709-714
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: Breast-feeding;breast-milk;perinatal HIV-1 infection;Zaire;dose-response;human milk
数据来源: OVID
摘要:
Breast-feeding as a route of HIV-1 transmission during infancy but also as a protective measure against early childhood morbidity has been investigated prospectively in children born to HIV-1-seropositive mothers and control children born to age- and parity-matched HIV-1 -seronegative women. The mothers of all study children had been enrolled antenatally at a maternity hospital in Kinshasa, Zaire, which served a relatively affluent group of women who sometimes chose not to breast-feed their infants. In 106 children born to HIV-1-seropositive women, the rate of HIV-1 transmission was 21% in 28 infants exclusively breast-fed, 19% in 68 infants both breast- and bottle-fed and 0% in 10 infants who were bottle-fed only (P = 0.35). In contrast, non-HIV-1-infected children of both HIV-1-seropositive and HIV-1-seronegative mothers who were exclusively breast-fed compared with uninfected children who were not exclusively breast-fed had significantly lower incidence rates of acute diarrhea, fever and lower respiratory tract infection. The lack of a dose-response effect between breast-feeding and perinatal HIV-1 transmission and the presence of a protective effect of breast-feeding against common causes of early childhood morbidity and mortality support the current World Health Organization recommendation that breast-feeding should continue to be promoted in all developing countries, including those with high HIV-1 prevalence rates in women of childbearing age.
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