Advantage of Hand Bone Calcium Content Measurement by Local Neutron Activation Analysis for Following Up Hemodialysis Patients
作者:
D. Kuntz,
B. Maziere,
J.L. Sebert,
P. Moriniere,
P.J. Meuniere,
N. Duquesnoy,
A. Fournier,
期刊:
Nephron
(Karger Available online 1983)
卷期:
Volume 34,
issue 4
页码: 228-233
ISSN:1660-8151
年代: 1983
DOI:10.1159/000183021
出版商: S. Karger AG
关键词: Hand bone calcium;Neutron activation;Hemodialysis;Vitamin D;Secondary hyperparathyroidism
数据来源: Karger
摘要:
Hand bone calcium content [Ca] has been measured by local neutron analysis in hemodialyzed patients free of signs of osteomalacia before and 6–12 months after treatment with vitamin D metabolites, and it has been compared to some iliac bone histomorphometric parameters. With 1,25-(OH)2D3 alone, [Ca] increases significantly at the 6th month of treatment (p < 0.001) but not from the 6th to the 12th month. With 1α-(OH)D3 + 25-(OH)D3 the same phenomenon is observed at the 6th and 12th months of treatment. Before treatment, [Ca] was correlated negatively with the osteoid surfaces (OS) (r = – 0.62, p = 0.01) and the number of osteoclasts per square millimeter (Ocl/mm2)(r = -0.79, p < 0.001). At the 6th month of treatment, [Ca] was still correlated negatively with OS (r = – 0.42, p = 0.05) and with Ocl/mm2 (r = -0.60, p < 0.005). At the 12th month, the two negative correlations decreased but remained significant (r = -0.42, p = 0.05; r = -0.45, p = 0.05). These data suggest that (1) hand bone calcium analysis by neutron activation permits to follow up the peripheral bone mineral content in hemodialyzed patients and (2) the [Ca] increase only observed during the first months of treatment with vitamin D metabolites probably result from an attenuation of secondary hyperparathyr
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